منابع مشابه
Diagnosing myocardial iron overload.
Cardiac failure or arrhythmia are the dominant causes of death in patients with thalassaemia major and other transfusion-dependent refractory anaemias. Each unit of blood contains 200–250 mg of iron and body iron stores are normally only 0·5–1·5 g. Since the body has no physiological mechanism for excreting iron, repeated blood transfusions result in iron accumulation in the reticuloendothelial...
متن کاملMyocardial iron overload in sickle/thalassemia patients of Italian origin
Background Sickle-thalassemia is an inherited hemoglobin disorder resulting from the combined heterozygosity for sicklecell and b-thalassemia genes. Myocardial iron overload in patients with sickle-thalassemia has been poorly studied; however, a report has shown no evidence of cardiac iron in a small group (n=10) of multitransfused Arab patients. The current study aims to further evaluate cardi...
متن کاملMyocardial iron overload in thalassaemia major. How early to check?
The age at which it is necessary to start Cardiovascular Magnetic Resonance (CMR) T2* screening in thalassaemia major (TM) is still uncertain. To clarify this point, we evaluated the prevalence of myocardial iron overload (MIO), function and fibrosis by CMR in TM patients younger than 10 years. We retrospectively selected 35 TM patients enrolled in the Myocardial Iron Overload in Thalassaemia n...
متن کاملMyocardial iron overload in thalassemia major. How early to check?
Methods From the 2171 patients enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) network, we retrospectively selected the 35 TM patients aged less than 10 years who had undergone at least one MRI scan. Myocardial iron overload (MIO) was measured by T2* multislice multiecho technique. Biventricular function parameters were quantitatively evaluated in a standard way by cine images. T...
متن کاملIron overload.
Dietary copper in the U.S. often is lower than that proved insufficient for men and women under controlled conditions. Iron overload can have adverse effects on copper nutriture and can produce cardiac disease in people. The hypothesis that iron can interfere with copper utilization to produce adverse effects related to cardiovascular function was tested. Rats were fed a diet high in iron and m...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2001
ISSN: 0195-668X
DOI: 10.1053/euhj.2001.2951